Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
form
Powder
pka
2.68±0.10(Predicted)
Usage And Synthesis
Uses
FR 139317 is a novel, potent endothelin ETA receptor antagonist.
Biological Activity
A highly potent and selective ET A endothelin receptor antagonist (K i values are 1 nM and 7.3 μ M at ET A and ET B subtypes respectively). Active in vivo .
