4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
英文名称:4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
CAS号:174264-46-1
分子式:C34H41NO4SSi
分子量:587.84414
EINECS号:
Mol文件:174264-46-1.mol
![4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 结构式](https://img.chemicalbook.com/CAS/GIF/174264-46-1.gif)
4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 性质
储存条件 | Refrigerator |
---|---|
溶解度 | 可溶于丙酮、氯仿、二氯甲烷、乙醇、甲醇 |
形态 | 固体 |
颜色 | 粘黄色 |
CAS 数据库 | 174264-46-1 |
4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 用途与合成方法
4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) 是一种Raloxifene 与叔丁基二甲基甲硅烷基氯的反应产物。4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 可用于合成 Raloxifene 6-glucuronide。
The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide.
4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene供应商 更多
北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
英文名称:4'-tert-ButyldiMethylsilyl-6-hydroxy Raloxifene
CAS:174264-46-1
包装信息:100Mg,1g
备注:化学试剂、精细化学品、医药中间体、材料中间体
深圳聚合生化科技有限公司
联系电话:+86-400-002-6226 13028896684
产品介绍:
英文名称:4'-tert-ButyldiMethylsilyl-6-hydroxy Raloxifene
CAS:174264-46-1
安耐吉化学&3A(安徽泽升科技有限公司)
联系电话:021-58432009 400-005-6266
产品介绍:
英文名称:4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
CAS:174264-46-1
纯度:NULL
包装信息:100mg;1g;250mg;500mg;50mg
备注:NULL
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
CAS:174264-46-1
包装信息:50mg
备注: 试剂级
湖北国云福瑞科技有限公司
联系电话: 18162595016
产品介绍:
英文名称:Sulfamic Acid Impurity 6
CAS:174264-46-1
纯度:95%+HPLC
包装信息:10mg;25mg;50mg;100mg;200mg
备注:可配合各项资料,随货提供COA HNMR MS HPLC 等;CNMR IR UV 二维谱 水分 含量图谱等资料也均可提供