1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol (1-AG; Item No. 62150).1 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM.2 It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS.3 It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.4WARNING This product is not for human or veterinary use.

[1] SHINJI NAKANE . 2-Arachidonoyl-sn-glycero-3-phosphate, an arachidonic acid-containing lysophosphatidic acid: occurrence and rapid enzymatic conversion to 2-arachidonoyl-sn-glycerol, a cannabinoid receptor ligand, in rat brain[J]. Archives of biochemistry and biophysics, 2002, 402 1: Pages 51-58. DOI: 10.1016/s0003-9861(02)00038-3
[2] KOJI BANDOH . Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species[J]. FEBS Letters, 2000, 478 1: Pages 159-165. DOI: 10.1016/s0014-5793(00)01827-5
[3] JASON EMO. Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.[J]. Journal of immunology, 2012: 3784-3790. DOI: 10.4049/jimmunol.1102956
[4] MAYUMI HIDAKA  Akira T  Mai Nishihara. Three lysophosphatidic acids with a distinct long chain moiety differently affect cell differentiation of human colon epithelial cells to goblet cells[J]. Life sciences, 2018, 197: Pages 73-79. DOI: 10.1016/j.lfs.2018.02.003