FSH receptor-binding inhibitor fragment(bi-10) (10, 20, 30, 40 mg/kg; Intramuscularly injection; once a day for five consecutive days) with high dose (30 mg/kg to 40 mg/kg) can suppress ovarian and follicular development, and attenuate expression levels of ERβ and FSHR mRNAs and proteins in the ovaries, additionally inhibit E2 production[1].
| Animal Model: | Prepuberty Kunming female mice of 21-days old and body weight of 22.3±1.52g[1] |
| Dosage: | 10, 20, 30, 40 mg/kg |
| Administration: | Intramuscularly injection; once a day for five consecutive days |
| Result: | Could attenuate FSH promoting effect on the follicular development, resulting in the poor maturation of ovarian follicles.
High dose (40mg/kg) treatment blocked the follicle development of mice.
High dose of FRBI (40mg/kg) treatment blocked the follicle development of mice.
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