PAMAM Dendrimer G2.0 Amidoethanol (water solution)

PAMAM dendrimer G2.0 amidoethanol (PAMAM G2.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini that has been used as a drug delivery system in vitro.1,2 It is approximately 29.4 Å in diameter in water and has 16 surface groups.3 PAMAM G2.0 amidoethanol is an antagonist of the pore-forming channel binary anthrax toxin protective antigen 63 (PA63) in lipid bilayers (IC50 = 142 nM).4 It inhibits the proliferation of MCF-7 and MDA-MB-231 breast cancer cells when used at a concentration of 100 µM.5 PAMAM G2.0 amidoethanol enhances the water solubility of the antibiotic erythromycin (Item No. 16486) and increases the antifungal activity of clotrimazole (Item No. 15278WARNING This product is not for human or veterinary use.

[1] KATARZYNA WINNICKA. The effect of PAMAM dendrimers on the antibacterial activity of antibiotics with different water solubility.[J]. Molecules, 2013, 18 7: 8607-8617. DOI: 10.3390/molecules18078607
[2] KATARZYNA WINNICKA. Poly(amidoamine) dendrimers increase antifungal activity of clotrimazole.[J]. Biological & pharmaceutical bulletin, 2011, 34 7: 1129-1133. DOI: 10.1248/bpb.34.1129
[3] SOLEDAD GONZALO. First evidences of PAMAM dendrimer internalization in microorganisms of environmental relevance: A linkage with toxicity and oxidative stress.[J]. Nanotoxicology, 2015, 9 6: 706-718. DOI: 10.3109/17435390.2014.969345
[4] GOLI YAMINI E M N Nnanya Kalu. Impact of Dendrimer Terminal Group Chemistry on Blockage of the Anthrax Toxin Channel: A Single Molecule Study[J]. Toxins, 2016, 8 1. DOI: 10.3390/toxins8110337
[5] K. WINNICKA. The Effect of Generation 2 and 3 Poly(amidoamine) Dendrimers on Viability of Human Breast Cancer Cells[J]. Journal of Health Science, 2009, 1 1: 169-177. DOI: 10.1248/jhs.55.169
[6] TE-HAW WU. Fluorescent Hydroxylamine Derived from the Fragmentation of PAMAM Dendrimers for Intracellular Hypochlorite Recognition†[J]. Chemistry - A European Journal, 2013, 19 35: 11672-11675. DOI: 10.1002/chem.201300494