Gap 27 (trifluoroacetate salt)

Gap 27 is a connexin-mimetic peptide that corresponds to amino acids 204-214 of extracellular loop 2 in connexin 43.1 It reduces survival of isolated rat osteoclasts when used at a concentration of 500 µM and decreases bone resorption in rat bone slice and osteoclast co-cultures.2 Gap 27 accelerates wound closure and stratification of the corneal epithelium in isolated human corneas.3 In vivo, Gap 27 reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of arterio-venous fistula (AV-shunt) surgery-induced high-output heart failure.4WARNING This product is not for human or veterinary use.

[1] CATHERINE S. WRIGHT. The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitro[J]. Journal of Cellular Physiology, 2011, 227 1: 77-87. DOI: 10.1002/jcp.22705
[2] J. ILVESARO J T P Tavi. Connexin-mimetic peptide Gap 27 decreases osteoclastic activity[J]. BMC Musculoskeletal Disorders, 2001, 2 1: 10-10. DOI: 10.1186/1471-2474-2-10
[3] HOSSEIN MOSTAFA ELBADAWY. Effect of connexin 43 inhibition by the mimetic peptide Gap27 on corneal wound healing, inflammation and neovascularization[J]. British Journal of Pharmacology, 2016, 173 19: 2880-2893. DOI: 10.1111/bph.13568
[4] CLAUDIA M LUCERO. Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats.[J]. Scientific Reports, 2020: 6878. DOI: 10.1038/s41598-020-63336-6