Substance P (1-7) (trifluoroacetate salt)

Substance P (1-7) is a peptide fragment of the neuropeptide substance P (Item No. 24035).1 It is produced by proteolytic cleavage of substance P by neprilysin. Substance P (1-7) (10 nM) induces internalization of the neurokinin-1 (NK1) receptor in isolated rat striatal slices.2 It inhibits substance P-induced contralateral rotation in rats and substance P-induced substantia nigra dopamine release in anesthetized rats.3 Administration of substance P (1-7) into the nucleus tractus solitarius decreases mean arterial pressure and heart rate in anesthetized rats.1 Substance P (1-7) (1 nmol/animal) reduces withdrawal jumping in morphine-dependent mice when administered intrathecally.4 It increases the latency to tail-flick in the tail-flick test in streptozotocin-induced diabetic mice, an effect that can be reversed by naloxone or (+)-pentazocine but not naltrindole (Item No. 9000705), β-funaltrexamine (Item No. 39901), norbinaltorphimine, or BD 1047 (Item No. 22928).5 Substance P (1-7) (35 pmol/animal) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic-like activity.6WARNING This product is not for human or veterinary use.

[1] MICHAEL E. HALL  John M S  Francis Miley. The role of enzymatic processing in the biological actions of substance P[J]. Peptides, 1989, 10 4: Pages 895-901. DOI: 10.1016/0196-9781(89)90132-0
[2] A T MICHAEL-TITUS. N- and C-terminal substance P fragments: differential effects on striatal [3H]substance P binding and NK1 receptor internalization.[J]. Neuroreport, 1999, 10 10: 2209-2213. DOI: 10.1097/00001756-199907130-00038
[3] MARIO HERRERA-MARSCHITZ . The substance P(1–7) fragment is a potent modulator of substance P actions in the brain[J]. Brain Research, 1990, 521 1: Pages 316-320. DOI: 10.1016/0006-8993(90)91558-x
[4] JULIE S. KREEGER  Alice A L. Substance P-(1–7), a substance P metabolite, inhibits withdrawal jumping in morphine-dependent mice[J]. European journal of pharmacology, 1993, 238 1: Pages 111-115. DOI: 10.1016/0014-2999(93)90513-h
[5] ANNA CARLSSON . Substance P1–7 induces antihyperalgesia in diabetic mice through a mechanism involving the naloxone-sensitive sigma receptors[J]. European journal of pharmacology, 2010, 626 2: Pages 250-255. DOI: 10.1016/j.ejphar.2009.10.006
[6] JOÃO E DE ARAÚJO  Marcus L B  Joseph P Huston. Opposite effects of substance P fragments C (anxiogenic) and N (anxiolytic) injected into dorsal periaqueductal gray[J]. European journal of pharmacology, 2001, 432 1: Pages 43-51. DOI: 10.1016/s0014-2999(01)01460-1