Epitalon (trifluoroacetate salt)

Epitalon is a synthetic tetrapeptide with anti-aging activities.1,2,3,4 It increases the lifespan of D. melanogaster imagoes when used at concentrations ranging from 0.001 to 5% in the culture medium.1 Epitalon (1 μg/animal) delays age-related estrous cycle shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice when administered at a dose of 0.1 µg/animal.3 Epitalon (10 µg/animal) also stimulates melatonin synthesis in the evening and restores the circadian rhythm of cortisol secretion in senescent M. mulatta monkeys.4WARNING This product is not for human or veterinary use.

[1] V.KH. KHAVINSON . Effect of epitalon on the lifespan increase in Drosophila melanogaster[J]. Mechanisms of Ageing and Development, 2000, 120 1: Pages 141-149. DOI: 10.1016/s0047-6374(00)00217-7
[2] VLADIMIR N ANISIMOV. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.[J]. Biogerontology, 2003, 4 4: 193-202. DOI: 10.1023/a:1025114230714
[3] GEORGE KOSSOY. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.[J]. In vivo, 2006, 20 2: 253-257.
[4] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.