4-amidinoindan-1-one 2'-amidinohydrazone

Product Name4-amidinoindan-1-one 2'-amidinohydrazone
CAS149400-88-4
MFC11H14N6
MW230.27
EINECS
MOL File149400-88-4.mol

Chemical Properties

Boiling point	438.8±55.0 °C(Predicted)
Density	1.54±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	Soluble in DMSO
pka	11.54±0.20(Predicted)

Usage And Synthesis

Uses

Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.

Biological Activity

Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with IC50 of 5 nM.

in vitro

Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC ₅₀ of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells.

target

IC50: 5 nM (SAMDC)

References

[1] Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7. PMID:8205541
[2] Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90. PMID:9731498