Amprenavir-d4-1

Amprenavir-d₄ is intended for use as an internal standard for the quantification of amprenavir by GC- or LC-MS. Amprenavir is an inhibitor of HIV protease (K_i = 0.04 nM).¹ It inhibits the cytopathic effects of HIV-1 in MT-4 cells (IC₅₀ = 150 nM). Formulations containing amprenavir have been used in combination with other antiretroviral agents in the treatment of HIV-1 infection.

Amprenavir-d4-1 is deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.

1. Sherrill, R.G., Furfine, E.S., Hazen, R.J., et al. Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors Bioorg. Med. Chem. Lett. 15(15),3560-3564(2005).