2-Deoxy-D-glucose-6-phosphate

2-Deoxy-D-glucose 6-phosphate is an intermediate of 2-deoxy-D-glucose (2-DG) [1]. 2-Deoxy-D-glucose is incorporated into glycogen[2].

ChEBI: A deoxyaldohexose phosphate comprising 2-deoxy-D-glucose having the phosphate group at the 6-position.

[1] Kuo SC, et al. Inhibition by 2-deoxy-D-glucose of synthesis of glycoprotein enzymes by protoplasts of Saccharomyces: relation to inhibition of sugar uptake and metabolism. J Bacteriol. 1972;111(2):419-429. DOI:10.1128/jb.111.2.419-429.1972
[2] Doenst T, et al. Complexities underlying the quantitative determination of myocardial glucose uptake with 2-deoxyglucose. J Mol Cell Cardiol. 1998;30(8):1595-1604. DOI:10.1006/jmcc.1998.0725
[3] Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29. DOI:10.3390/ijms21010234
[4] Paternostro G, et al. Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. Cardiovasc Res. 1995;30(2):205-211. PMID:7585807