4,7,11,13,15,19-Docosahexaenoic acid, 10,17-dihydroxy-, methyl ester, (4Z,7Z,10R,11E,13E,15Z,17S,19Z)-

Protectin D1 methyl ester is an esterified form of the specialized pro-resolving mediator protectin D1 . It is an intermediate in the synthesis of protectin D1.¹ Protectin D1 methyl ester (333 μg/kg) reduces infarct area and volume and increases blood vessel density in the tissue surrounding the infarct in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).²

1. Rodriguez, A.R., and Spur, B.W. Total synthesis of the potent anti-inflammatory lipid mediator Protectin D₁ Tetrahedron Lett. 55(43),6011-6015(2014).
2. Bazan, N.G., Eady, T.N., Khoutorova, L., et al. Novel aspirin-triggered neuroprotectin D₁ attenuates cerebral ischemic injury after experimental stroke Exp. Neurol. 236(1),122-130(2012).