Description
Protectin D1 methyl ester is an esterified form of the specialized pro-resolving mediator protectin D1 . It is an intermediate in the synthesis of protectin D1.
1 Protectin D1 methyl ester (333 μg/kg) reduces infarct area and volume and increases blood vessel density in the tissue surrounding the infarct in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).
2
References
1. Rodriguez, A.R., and Spur, B.W.
Total synthesis of the potent anti-inflammatory lipid mediator Protectin D1 Tetrahedron Lett. 55(43),6011-6015(2014).
2. Bazan, N.G., Eady, T.N., Khoutorova, L., et al.
Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke Exp. Neurol. 236(1),122-130(2012).
