艾默德斯
艾默德斯 性质
| 沸点 | 1219.3±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.104±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥31mg/mL（27.69mM） |
| 酸度系数(pKa) | 5.34±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
艾默德斯 用途与合成方法
| Target | Value |
|
Ca-dependent SLO-1-like K channels
() |
Emodepside is a semisynthetic derivative of PF1022A, which contains a morpholine attached in para position at each of both D-phenyllactic acids. Emodepside is efficacious against a variety of gastrointestinal nematodes. Emodepside binds to a presynaptic latrophilin receptor in nematodes. Emodepside produces a slow time-dependent (20 min), 4-aminopyridine sensitive, concentration-dependent hyperpolarization and increase in voltage-activated K currents. Emodepside has an inhibitory effect on spiking. Emodepside significantly inhibits the ryanodine increase in spike frequency between the 20 and 35 min period by 9.8 spikes/min. In the presence of emodepside, highly increased currents are observed without depolarization up to a threshold of 0 mV and without any additional stimuli to artificially increase [Ca 2+ ]i levels. These novel findings confirm that Slo-1 is a direct target of emodepside.
Emodepside interferes with signaling at the neuromuscular junction on the body-wall muscles, pharynx and egg-laying muscles and thus inhibits three important physiological functions: locomotion, feeding and reproduction.
艾默德斯 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-101476 | 1 mg | 636 | ||
| 2024-11-08 | HY-101476 | 艾默德斯 | 155030-63-0 | 5mg | 1400 |
