Lintopride

Product NameLintopride
CAS107429-63-0
MFC14H19ClN4O2
MW310.78
EINECS
MOL File107429-63-0.mol

Chemical Properties

Boiling point	494.1±45.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	13.20±0.46(Predicted)
color	Light yellow to yellow

Usage And Synthesis

Uses

Lintopride, a benzamide, is a potent 5HT-4 antagonist with moderate 5HT-3 antagonist properties. Lintopride increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animal. Lintopride significantly increases the lower oesophageal sphincter (LOS) basal tone[1].

Biological Activity

Lintopride is a 5HT4 antagonist with a slight antagonistic effect on 5HT3.

in vitro

Lintopride significantly increases the lower oesophageal sphincter basal tone without affecting lower oesophageal sphincter physiological relaxation after swallowing. Peristaltic waves are also enhanced by Lintopride.

target

5-HT ₄ Receptor

5-HT ₃ Receptor

IC 50

5-HT₄ Receptor; 5-HT₃ Receptor

References

[1] Delvaux M, et al. The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9. DOI:10.1111/j.1365-2036.1995.tb00422.x