JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM.
JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]
JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes.
ChEBI: [2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.
Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
[1] YAEL FRIEDMANN. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast.[J]. Molecular Pharmacology, 2006, 70 4: 1395-1405. DOI:
10.1124/mol.106.022962
