Amino-PEG23-amine

＞98%

Amino-PEG23-amine (CAS 2673284-93-8), also known as H₂N-PEG23-CH₂CH₂NH₂, NH₂-PEG23-NH₂ and H₂N-PEG23-CH₂CH₂NH₂, is a high-purity, symmetrical, homobifunctional PEG linker. Its molecular structure contains two terminal amino groups, which can react with carboxylic acids, activated NHS esters, and carbonyl groups (ketones, aldehydes). This compound is primarily used in the synthesis of PROTACs and polymer hydrogels, the surface modification of nanformulations and liposomes, and antibody-drug conjugates (ADCs).

Amino-PEG23-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005