GIMATECAN
中文名称:GIMATECAN
英文名称:ST1481
CAS号:292618-32-7
分子式:C25H25N3O5
分子量:447.488
EINECS号:
Mol文件:292618-32-7.mol
![GIMATECAN 结构式](https://img.chemicalbook.com/CAS/GIF/292618-32-7.gif)
GIMATECAN 性质
沸点 | 780.6±70.0 °C(Predicted) |
---|---|
密度 | 1.37±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
酸度系数(pKa) | 11.20±0.20(Predicted) |
形态 | 固体 |
颜色 | 浅黄至黄色 |
GIMATECAN 用途与合成方法
Gimatecan (ST1481) 是一种有效的拓扑异构酶 I (topoisomerase I) 抑制剂。Gimatecan 是一种具有口服活性的喜树碱类似物。具有抗肿瘤活性。
Topoisomerase I
|
Gimatecan (3 to 300 ng/mL) significantly inhibits the growth of human bladder cancer models (HT1376 and MCR), thus reflecting antiproliferative potency.
Gimatecan causes a persistent S-phase arrest At 0.003 µg/mL and the number of S-phase cells increased after treatment with a higher concentration (0.03 µg/mL).
Cell Proliferation Assay
Cell Line: | HT1376 cells harbor a p53 mutation; MCR cells harbor two p53 mutations: one in exon 4 (CGC→CCC) and one in exon 9 (CAG→TAG) |
Concentration: | 3 to 300 ng/mL |
Incubation Time: | 1, 6, and 24 hours |
Result: |
IC
50
s of 90±3 and 9.0±0.4 ng/mL for MCR and HT1376 cells after treatment for 1 hours.
IC 50 s of 5.0±0.2 and 2.8±0.1 ng/mL for MCR and HT1376 cells after treatment for 24 hours. The growth-inhibitory effect was dose-dependent and time-dependent. HT1376 cells were more sensitive than MCR cells at least following a short-term exposure. |
Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth.
Animal Model: | Athymic Swiss nude mice bearing HT1376 model |
Dosage: | 2 mg/kg |
Administration: | Treatment per os, every fourth day for four times |
Result: | Caused a marked tumor growth inhibition during treatment. |
GIMATECAN 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-04-30 | HY-B0063 | 1 mg | 1400 | ||
2024-04-30 | HY-B0063 | GIMATECAN | 292618-32-7 | 10 mg | 5800 |
GIMATECAN供应商 更多
上海特伯化学科技有限公司
联系电话:021-58170097
产品介绍:
英文名称:Gimatecan
CAS:292618-32-7
纯度:98%
包装信息:1g;10g;100g
备注:现货
上海昕凯医药科技有限公司
联系电话:21-619849051-1 18521059765
产品介绍:
英文名称:ST1481
CAS:292618-32-7
纯度:98%+
包装信息:50mg,500mg,1g or as requested
南京安美科技有限公司
联系电话:025-84767922 18936879710
产品介绍:
中文名称:吉马替康
英文名称:Gimatecan
CAS:292618-32-7
纯度:99%
包装信息:500g,100g,10g,1g
备注:医药级
上海朗旭生物科技有限公司
联系电话:+86-021-51783479 +86-13816874662
产品介绍:
英文名称:Gimatecan
CAS:292618-32-7
纯度:99%min hplc
包装信息:1g,10g,100g
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:吉马替康
英文名称:Gimatecan
CAS:292618-32-7
纯度:98.47%
包装信息:1 mg;10 mg;100 mg;25 mg;5 mg;50 mg