GIMATECAN
中文名称:GIMATECAN
英文名称:ST1481
CAS号:292618-32-7
分子式:C25H25N3O5
分子量:447.488
EINECS号:
Mol文件:292618-32-7.mol
GIMATECAN 性质
| 沸点 | 780.6±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.37±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 11.20±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
GIMATECAN 用途与合成方法
Gimatecan (ST1481) 是一种有效的拓扑异构酶 I (topoisomerase I) 抑制剂。Gimatecan 是一种具有口服活性的喜树碱类似物。具有抗肿瘤活性。
|
Topoisomerase I
|
Gimatecan (3 to 300 ng/mL) significantly inhibits the growth of human bladder cancer models (HT1376 and MCR), thus reflecting antiproliferative potency.
Gimatecan causes a persistent S-phase arrest At 0.003 µg/mL and the number of S-phase cells increased after treatment with a higher concentration (0.03 µg/mL).
Cell Proliferation Assay
| Cell Line: | HT1376 cells harbor a p53 mutation; MCR cells harbor two p53 mutations: one in exon 4 (CGC→CCC) and one in exon 9 (CAG→TAG) |
| Concentration: | 3 to 300 ng/mL |
| Incubation Time: | 1, 6, and 24 hours |
| Result: |
IC
50
s of 90±3 and 9.0±0.4 ng/mL for MCR and HT1376 cells after treatment for 1 hours.
IC 50 s of 5.0±0.2 and 2.8±0.1 ng/mL for MCR and HT1376 cells after treatment for 24 hours. The growth-inhibitory effect was dose-dependent and time-dependent. HT1376 cells were more sensitive than MCR cells at least following a short-term exposure. |
Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth.
| Animal Model: | Athymic Swiss nude mice bearing HT1376 model |
| Dosage: | 2 mg/kg |
| Administration: | Treatment per os, every fourth day for four times |
| Result: | Caused a marked tumor growth inhibition during treatment. |
GIMATECAN 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-B0063 | 1 mg | 1400 | ||
| 2024-11-08 | HY-B0063 | GIMATECAN | 292618-32-7 | 5mg | 3500 |
GIMATECAN供应商 更多
上海特伯化学科技有限公司
联系电话：021-58170097
产品介绍：
英文名称：Gimatecan
CAS：292618-32-7
纯度：98%
包装信息：1g;10g;100g
备注：现货
上海昕凯医药科技有限公司
联系电话：21-619849051-1 18521059765
产品介绍：
英文名称：ST1481
CAS：292618-32-7
纯度：98%+
包装信息：50mg,500mg,1g or as requested
上海朗旭生物科技有限公司
联系电话：+86-021-51783479 +86-13816874662
产品介绍：
英文名称：Gimatecan
CAS：292618-32-7
纯度：99%min hplc
包装信息：1g,10g,100g
河北药成医药科技有限责任公司
联系电话：0311-88802076 13171568381
产品介绍：
英文名称：Gimatecan
CAS：292618-32-7
纯度：95%
包装信息：5g100gkg级
备注：小量现货，量大从优
上海毕得医药科技股份有限公司
联系电话：400-1647117 13681763483
产品介绍：
中文名称：(S,E)-4-乙基-4-羟基-3,14-二氧代-3,4,12,14-四氢-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-b]喹啉-11-甲醛 O-(叔丁基)肟
英文名称：(S,E)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carbaldehyde O-(tert-butyl) oxime
CAS：292618-32-7
纯度：98%
包装信息：10mg;25mg;50mg;100mg;250mg;
备注：BD151872
