Clavulanate Lithium

Clavulanate Lithium is a beta-lactamase inhibitor. It can irreversibly inactivate beta-lactamase enzymes of beta-lactam resistant microbes preventing them from breaking down beta-lactam antibiotics.

Clavulanic acid, lithium salt or lithium clavulanate is an irreversible inhibitor of β-lactamase class A enzymes, which target β-lactam antibiotics. Clavulanic acid, lithium salt has been shown operate more efficiently with ceftazidime and amoxicillin antibiotics. Research has also shown an increase in AmpC β-lactamase expression when lithium clavulanate was administered in vitro to Enterobacteriaceae.