Recombinant Human Vegf

Product NameRecombinant Human Vegf
CAS127464-60-2
MFNULL
MW0
EINECS
MOL FileMol File

Chemical Properties

storage temp.	-20°C
form	powder
color	white
biological source	rat

Safety Information

Safety Statements	22-24/25
WGK Germany	3

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

VEGF human has been used as a chemoattractant for HUVECs (human umbilical vein endothelial cells) migration assay.

General Description

VEGF (vascular endothelial growth factor) signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant human VEGF is a 38.2kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

Biochem/physiol Actions

VEGF (vascular endothelial growth factor) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intraocular neovascular syndromes. Polymorphism in VEGF at C(-634)G is linked with diabetic retinopathy in type 2 diabetes.