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MK-1775

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955365-80-7 Basic informationMore
USE
MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.
Lastest Price from MK-1775 manufacturers
  • MK-1775
  • US $0.00 /KG
  • CAS:955365-80-7
  • Min. Order: 1KG
  • Purity: 98.1%
  • Supply Ability: 100 tons
  • 2022-01-14
  • Adavosertib
  • US $1.50 /g
  • CAS:955365-80-7
  • Min. Order: 100g
  • Purity: 99%
  • Supply Ability: 500ton/Month
  • 2021-11-15

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