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Axitinib

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319460-85-0 Basic informationMore
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In January 2012, the US FDA approved axitinib (also referred to as AG-013736) for the treatment of advanced renal cell carcinoma (RCC) for patients who have not responded to prior therapy. Axitinib is a pan VEGF inhibitor and functions by binding to the intracellular tyrosine kinase catalytic domain of VEGF leading to blockade of signaling through this angiogenic pathway. Axitinib is50–400 times more potent for VEGF (enzyme Ki and cellular IC<sub>50s</sub> for VEGF 1, 2, and 3 are ~0.1 nM) than first-generation inhibitors like sorafenib and sunitinib. Axitinib also inhibits c-Kit and PDGFR(α/β) with enzyme Ki's of ~2 nM and was selective when tested against a broad panel of other protein kinases. Axitinib was discovered by a structure-based drug design approach and binds to the kinase domain of VEGF in a DFG-out conformation. Axitinib blocks VEGF-2 phosphorylation up to 7 h postdose in vivo and inhibits endothelial cell proliferation in xenograft tumors implanted in mice. Synthetic routes to axitinib employing a Migita coupling to form the diaryl sulfide and a Heck reaction to install the 2-styrylpyridine moiety have been reported.
Lastest Price from Axitinib manufacturers
  • Axitinib
  • US $1.00-0.50/kg
  • CAS:319460-85-0
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 200
  • 2024-03-28
  • Axitinib
  • US $5.00-0.10/KG
  • CAS:319460-85-0
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: g-kg-tons, free sample is available
  • 2024-03-26

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  • Company Name:Shanghai Scientia Pharmaceutical Technology Co., Ltd.
  • Tel:21-21-54301573 13917723525
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  • Tel:010-82848833 400-666-7788
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  • Company Name:Chembest Research Laboratories Limited
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    Remarks:C13343 More...
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  • Company Name:BeiJing Hwrk Chemicals Limted
  • Tel:0757-86329057 18501085097
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    Purity:99.00% Package:250mg Remarks:HWG46793
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