Axitinib
319460-85-0 Basic informationMore
- Product Name:Axitinib
- Synonyms: N-METHYL-2-{[3-((E)-2-PYRIDIN-2-YLVINYL)-1H-INDAZOL-6-YL]SULFANYL}BENZAMIDE AVERMECTINB Axitinib for research AG 013736 Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]- Axtinib N-Methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzaMide 10MG/50MG/100G
- CAS:319460-85-0
- MF:C22H18N4OS
- MW:386.47
- EINECS:638-771-6
- Mol File:319460-85-0.mol
-
USE
In January 2012, the US FDA approved axitinib (also referred to as
AG-013736) for the treatment of advanced renal cell carcinoma (RCC)
for patients who have not responded to prior therapy.
Axitinib is a pan VEGF inhibitor and functions by binding to
the intracellular tyrosine kinase catalytic domain of VEGF leading to blockade of signaling through this angiogenic pathway. Axitinib is50–400 times more potent for VEGF (enzyme Ki and cellular IC<sub>50s</sub> for VEGF 1, 2, and 3 are ～0.1 nM) than first-generation inhibitors like sorafenib and sunitinib. Axitinib also inhibits c-Kit and PDGFR(α/β) with enzyme Ki's of
～2 nM and was selective when tested against a broad panel of other protein
kinases. Axitinib was discovered by a structure-based drug design approach
and binds to the kinase domain of VEGF in a DFG-out conformation.
Axitinib blocks VEGF-2 phosphorylation up to 7 h postdose in vivo and
inhibits endothelial cell proliferation in xenograft tumors implanted in
mice. Synthetic routes to axitinib employing a Migita coupling to form
the diaryl sulfide and a Heck reaction to install the 2-styrylpyridine moiety have been reported.
Lastest Price from Axitinib manufacturers
- Axitinib
-
- US $0.00-0.00/kg
- CAS:319460-85-0
- Min. Order: 100kg
- Purity: ≥99% by HPLC
- Supply Ability: 10kg/Month
- 2024-12-18
- Axitinib
-
- US $1.00-0.50/kg
- CAS:319460-85-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 200
- 2024-12-18
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- Company Name:Shanghai Scientia Pharmaceutical Technology Co., Ltd.
- Tel:21-21-54301573 13917723525
- Products Intro:Product Name:Axitinib
CAS:319460-85-0
Purity:99%min Package:1000kg More... - CB Index:62
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- Company Name:Jinan XinKe Pharmaceutical Technology Co., Ltd.
- Tel:0531-88259693 17854196142
- Products Intro:Product Name:Axitinib
CAS:319460-85-0
Purity:≥99% HPLC Package:10g;100g;1000g More... - CB Index:58
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- Company Name:Sichuan Qingmu Pharmaceutical Co., Ltd.
- Tel:028-87827187 13419034739
- Products Intro:Product Name:axitinib
CAS:319460-85-0
Package:1kg - CB Index:60
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Axitinib, 98%
CAS:319460-85-0
Purity:98% Package:50MG More... - CB Index:76
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- Company Name:Bayee Biotech (Anqing) Co., Ltd.
- Tel:0556-5032306 18917961636
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CAS:319460-85-0
Purity:98% Package:100G;1KG;5kg More... - CB Index:61
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Axitinib(AG013736)
CAS:319460-85-0
Remarks:C13343 More... - CB Index:61
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- Company Name:Beijing HwrkChemical Technology Co., Ltd
- Tel:010-89508211 18501085097
- Products Intro:Product Name:Axitinib
CAS:319460-85-0
Purity:99.00% Package:250mg Remarks:HWG46793 - CB Index:55
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