Trimetrexate glucuronate

• Product Name:Trimetrexate glucuronate
• Synonyms: Trimetrexate glucuronate 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediaminetrihydrochloride CI 898 dihydrochloride CI 898 TRIHYDROCHLORIDE 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine D-glucuronate CI 898 D-Glucuronic Acid Salt (Trimetrexate D-Glucuronic Acid Salt)
• CAS:82952-64-5
• MF:C25H33N5O10
• MW:563.56
• EINECS:
• Mol File:82952-64-5.mol
• 

Trimetrexate glucuronate is a nonclassical antifolate introduced in the U.S.A. and Canada as second-line therapy for the treatment of Pneumocystis carinii pneumonia (PCP) and toxoplasmosis in AIDS patients who are refractory or intolerant to co-trimoxazole therapy. Trimetrexate glucuronate is reportedly to be in clinical trials for the treatment of several types of cancer including colorectal, gastric, pancreas, prostate, bladder, lung, breast, head, and neck cancers. It is also in early clinical trials for topical use in treating psoriasis and as an oral drug to treat rheumatoid arthritis. The mechanism of action of trimetrexate glucuronate is via inhibition of the enzyme dihydrofolate reductase which mediates the reduction of dihydrofolate to tetrahydrofolic acid and results in disruption of DNA, RNA and protein synthesis, with consequent cell death. Due to its toxicity to bone marrow and the GI tract, trimetrexate glucuronate must be concurrently administered with leucovorin as a rescue agent.

• Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
• Tel:821-50328103-801 18930552037
• Products Intro:Product Name:CI 898 trihydrochloride;5-Methyl-6-[[(3,4,5-triMethoxyphenyl)aMino]Methyl]-2,4-quinazolinediaMinetrihydrochloride
  CAS:82952-64-5
  Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
• CB Index:69
• Related Information:Catalog(15839)

• Company Name:TargetMol Chemicals Inc.
• Tel: 15002134094
• Products Intro:Product Name:Trimetrexate glucuronate
  CAS:82952-64-5
  Package:50mg;25mg;100mg
• CB Index:58
• Related Information:Catalog(19703)