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637-07-0

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637-07-0 Basic informationMore
USE
Clofibrate is the drug of choice in the treatment of typeIII hyperlipoproteinemias and may also be useful, to a lesserextent, in types IIb and IV hyperlipoproteinemias. The drugis not effective in types I and IIa.<br/>Clofibrate can lower plasma concentrations of both triglyceridesand cholesterol, but it has a more consistent clinicaleffect on triglycerides. It also affects lipoprotein plasmalevels by enhancing removal of triglycerides from the circulationand causes reduction of VLDL by stimulatinglipoprotein lipase to increase the catabolism of this lipoproteinto LDL. Clofibrate lowers triglyceride levels in theserum much more than cholesterol levels and decreases levelsof FFAs and phospholipids. The lowering of cholesterollevels may result from more than one mechanism. Clofibrateinhibits the incorporation of acetate into the synthesis ofcholesterol, between the acetate and mevalonate step, by inhibitingsn-glyceryl-3-phosphate acyltransferase. Clofibratealso regulates cholesterol synthesis in the liver by inhibitingmicrosomal reduction of 3-hydroxy-3-methylglutaryl-CoA(HMG-CoA), catalyzed by HMG-CoA reductase. Clofibratemay lower plasma lipids by means other than impairment ofcholesterol biosynthesis, such as increasing excretionthrough the biliary tract.
Lastest Price from Clofibrate manufacturers
  • Clofibrate
  • US $11.00 /KG
  • CAS: 637-07-0
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000KG
  • 2019-07-06

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  • Tel:400-666-7788 +86-10-82848833
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  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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    Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
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  • Company Name:Adamas Reagent, Ltd.
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  • Company Name:Shanghai Longsheng chemical Co.,Ltd.
  • Tel:021-58099637,58099652,58099650,58099609 To 8009,8068; 13585536065,QQ:975986869
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