PF 3644022
1276121-88-0 Basic informationMore
- Product Name:PF 3644022
- Synonyms: PF 3644022 (10R)-9,10,11,12-Tetrahydro-10-Methyl-3-(6-Methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one MK2 INHIBITOR 8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 9,10,11,12-tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-, (10R)- (R)-10-Methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one MAPKAP kinase 2,monocytic,lipopolysaccharide,IL-6,TNFα,safety,Anti-inflammatory,PF3644022,orally,PRAK,efficacious,inhibit,PF-3644022,Mitogen-activated protein kinase activated protein kinase 2,p38 MAPK,Inhibitor,MK3,MAP kinase activated protein kinase 2,MAPKAPK2 (MK2),MAPK activated protein kinase 2,PF 3644022 (R)-10-Methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
- CAS:1276121-88-0
- MF:C21H18N4OS
- MW:374.46
- EINECS:
- Mol File:1276121-88-0.mol
-
USE
PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:PF-3644022
CAS:1276121-88-0
Package:100Mg,10Mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:Wuhan TCASChem Technology Co., Ltd.
- Tel:027-027-86697669 13986148687
- Products Intro:CAS:1276121-88-0
Purity:97% Package:5g,10g,25g,100g - CB Index:55
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- Company Name:Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel:028-81700200 18116577057
- Products Intro:Product Name:PF3644022
CAS:1276121-88-0
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g - CB Index:56
- Related Information:Catalog(7887)
- Company Name:Sigma-Aldrich
- Tel:021-61415566 800-8193336
- Products Intro:Product Name:PF-3644022 hydrate
CAS:1276121-88-0
Purity:>=98% (HPLC) Package:25MG Remarks:PZ0188-25MG More... - CB Index:80
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- Company Name:Shanghai Chaolan Chemical Technology Center
- Tel:QQ:65489617 15618227136
- Products Intro:Product Name:PF 3644022
CAS:1276121-88-0
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G - CB Index:58
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- Company Name:Shanghai SuperLan Chemcial Technique Centre
- Tel:021-2022843681 15618226720
- Products Intro:CAS:1276121-88-0
Purity:95% Package:1G,5G,10G,50G,100G,1KG - CB Index:58
- Related Information:Catalog(8752)
- Company Name:Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel:010-50973130 4009686088
- Products Intro:Product Name:PF-3644022
CAS:1276121-88-0
- CB Index:68
- Related Information:Catalog(29785)