LX-4211
1018899-04-1 Basic informationMore
- Product Name:LX-4211
- Synonyms: LX-4211 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(Methylthio)tetrahydro-2H-pyran-3,4,5-triol (5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-beta-L-xylopyranoside LX4211/LX-4211 LP 802034 LX4211 - L10525 LX-4211 (sotagliflozin) LX-4211, >=98%
- CAS:1018899-04-1
- MF:C21H25ClO5S
- MW:424.94
- EINECS:
- Mol File:1018899-04-1.mol
USE
<p>Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.<br>
<img id="ProductImg1" src="https://www.chemicalbook.com/NewsImg/2019-06-07/20196714474032002.png"><br>
Sotagliflozin synthesis</p>
<p>Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.<br>
<img id="ProductImg1" src="https://www.chemicalbook.com/NewsImg/2019-06-07/20196714474032002.png"><br>
Sotagliflozin synthesis</p>
Lastest Price from LX-4211 manufacturers
- LX-4211
- US $999.00-900.00/kg
- CAS:1018899-04-1
- Min. Order: 0.0010000000474974513kg
- Purity: 99%
- Supply Ability: 5000
- 2024-11-24
- Sotagliflozin,LX-4211, LP-802034, LX4211, LP802034
- US $0.00-0.00/kg
- CAS:1018899-04-1
- Min. Order: 1kg
- Purity: 99%,single impurity<0.1
- Supply Ability: 1 ton
- 2024-11-22
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- Company Name:Shanghai Changyan Chem & Tech Co., Ltd.
- Tel:021-20242659 18930833303
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