VcMMAE

• Product Name:VcMMAE
• Synonyms: VcMMAE Maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl-monomethyl auristatin E 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-y MC-VC-PAB-MMAE,MC-Val-Cit-PAB-MMAE maleimido-caproyl-val-Cit-PAB-MMAE VeMMAE EOS-60990 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-Uriedidopenamiamido)benzyl((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S),2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-y
• CAS:646502-53-6
• MF:C68H105N11O15
• MW:1316.63
• EINECS:
• Mol File:646502-53-6.mol
• 

VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. VcMMAE can be used to make antibody drug conjugate. VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer?

• MC-Val-Cit-PAB-MMAE
• 
• US $0.00 /mg
• CAS:646502-53-6
• Min. Order: 100mg
• Purity: >98.00%
• Supply Ability: 100mg
• 2024-03-29

• VCMMAE
• 
• US $15.00-10.00/KG
• CAS:646502-53-6
• Min. Order: 1KG
• Purity: 99%+ HPLC
• Supply Ability: Monthly supply of 1 ton
• 2021-07-13

• Company Name:Levena (Suzhou) Biopharma Co., Ltd.
• Tel:0512-81877925 051281877925
• Products Intro:Product Name:MC-VC-PAB-MMAE
  CAS:646502-53-6
  Purity:99%HPLC Package:10mg/RMB 3000;100mg1g
• CB Index:58
• Related Information:Catalog(48)

• Company Name:Shanghai ruichang pharmaceutical technology co., LTD
• Tel: 18621054990
• Products Intro:Product Name:VcMMAE
  CAS:646502-53-6
  Purity:0.95 Package:25mg, 50mg, 100mg, 1g More...
• CB Index:58
• Related Information:Catalog(674)

• Company Name:Haoyuan Chemexpress Co., Ltd.
• Tel:021-58950125 13564235507;
• Products Intro:Product Name:Vc-MMAE
  CAS:646502-53-6
  Purity:≥99% Package:500mg/RMB 5600;10g100g
• CB Index:58
• Related Information:Catalog(757)

• Company Name:Shanghai Send Pharmaceutical Technology Co., Ltd.
• Tel:+86-021-50266790 Q2816483246
• Products Intro:Product Name:VcMMAE
  CAS:646502-53-6
  Purity:98% Package:1g;50g;100g
• CB Index:50
• Related Information:Catalog(281)

• Company Name:Jinan Chengquan Chemical Co., Ltd
• Tel:13616405505 13616405505
• Products Intro:Product Name:VcMMAE
  CAS:646502-53-6
  Purity:98% HPLC Package:25G:50G;1KG Remarks:100
• CB Index:58
• Related Information:Catalog(104)

• Company Name:YJ Pharma
• Tel:13962794339 13962794339
• Products Intro:Product Name:VC-MMAE
  CAS:646502-53-6
  Purity:98% Package:5g;10g;500g；1kg
• CB Index:58
• Related Information:Catalog(148)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:VcMMAE
  CAS:646502-53-6
  Purity:98%+ HPLC Package:50mg;100mg;500mg;1g;5g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More...
• CB Index:61
• Related Information:Catalog(6008)