NPS 2390
226878-01-9 Basic informationMore
- Product Name:NPS 2390
- Synonyms: N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide N-(1-adamantyl)quinoxaline-2-carboxamide N-(Adamantan-1-yl)quinoxaline-2-carboxamide Inhibitor,NPS2390,Calcium-sensing receptor,NPS-2390,mGluR,inhibit,Metabotropic glutamate receptors,CaSR,NPS 2390 2-Quinoxalinecarboxamide, N-tricyclo[3.3.1.13,7]dec-1-yl-
- CAS:226878-01-9
- MF:C19H21N3O
- MW:307.39
- EINECS:
- Mol File:226878-01-9.mol
-
USE
Metabotropic glutamate receptors (mGluRs), mediate excitatory synaptic transmission in the central nervous system. Potent and selective antagonists of the type I mGluRs (mGluR1 and mGluR5) are of interest as novel therapeutics for the treatment of various CNS disorders, such as pain, epilepsy, and stroke. NPS 2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values equal to 5.2 and 82 nM, respectively). At concentrations up to 30 μM, NPS 2390 does not affect mGluR2 or mGluR8 or a standard collection of 37 additional receptors, ion channels, and enzymes. At a dose of 10 mg/kg, NPS 2390 displaced the specifically bound mGlu1R-selective antagonist, [3H]R214127, in rat cerebellum.
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- Company Name:DKMbiochem.Co. Ltd
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- Products Intro:Product Name:NPS2390
CAS:226878-01-9
Purity:98% Package:100mg,500mg,1g, 5g,10g - CB Index:58
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CAS:226878-01-9
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g - CB Index:55
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CAS:226878-01-9
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- Company Name:Shanghai Yu Ben Biotechnology Co., Ltd.
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- Products Intro:Product Name:N-TRICYCLO[3.3.1.13,7]DEC-1-YL-2-QUINOXALINECARBOXAMIDE
CAS:226878-01-9
Purity:98% Package:g; kg - CB Index:58
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