NVP-BEZ 235
915019-65-7 Basic informationMore
- Product Name:NVP-BEZ 235
- Synonyms: 4-[2,3-Dihydro-3-Methyl-2-oxo-8-(quinolin-3-yl)-1H-iMidazo[4,5-c]quinolin-1-yl]-alpha,alpha-diMethylbenzeneacetonitrile BEZ-235 2-methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 2-Methyl-2-[3-Methyl-2-oxo-8-(3-quinolinyl)-1-iMidazo[4,5-c]quinolinyl]propanenitrile BEZ235 (NVP-BEZ235, Dactolisib) 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl BEZ235 NVP-BEZ235(BEZ235) Dactolisib
- CAS:915019-65-7
- MF:C30H23N5O
- MW:469.55
- EINECS:1312995-182-4
- Mol File:915019-65-7.mol
-
USE
Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.[Cayman Chemical]
Lastest Price from NVP-BEZ 235 manufacturers
- NVP-BEZ 235
-
- US $15.00-10.00/KG
- CAS:915019-65-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-02
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- Company Name:ShangHai Biochempartner Co.,Ltd
- Tel:177-54423994 17754423994
- Products Intro:Product Name:BEZ235
CAS:915019-65-7
Purity:98% Package:10MG/0.00; More... - CB Index:62
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- Company Name:Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
- Tel:+86-027-59232304 15387063101
- Products Intro:Product Name:BEZ235
CAS:915019-65-7
Purity:98% Package:1KG；100g;1g,100mg - CB Index:58
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- Company Name:Jinan shenlikang chemical technology co. LTD
- Tel:0531-86092839 13153040268
- Products Intro:Product Name:NVP-BEZ 235
CAS:915019-65-7
Package:1kg/ - CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:NVP-BEZ 235
CAS:915019-65-7
Package:100Mg,10Mg More... - CB Index:76
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:NVP-BEZ235(BEZ235)
CAS:915019-65-7
Remarks:C13946 More... - CB Index:61
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- Company Name:BeiJing Hwrk Chemicals Limted
- Tel:0757-86329057 18934348241
- Products Intro:Product Name:NVP-BEZ235
CAS:915019-65-7
Purity:98.00% Package:1g Remarks:HWG51408 More... - CB Index:55
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