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Sitagliptin

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486460-32-6 Basic informationMore
USE
Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.
Lastest Price from Sitagliptin manufacturers
  • Sitagliptin
  • US $0.00-0.00/Kg/Bag
  • CAS:486460-32-6
  • Min. Order: 1Kg/Bag
  • Purity: 98.5% up
  • Supply Ability: 20tons
  • 2024-11-21
  • Sitagliptin
  • US $0.00-0.00/kg
  • CAS:486460-32-6
  • Min. Order: 1kg
  • Purity: 99%, Single impurity<0.1
  • Supply Ability: 1 ton
  • 2024-11-21

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    CAS:486460-32-6
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