Sitagliptin
486460-32-6 Basic informationMore
- Product Name:Sitagliptin
- Synonyms: Sitagliptin (3R)-3-AMino-1-[3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,2,4-riazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-rifluorophenyl) butan-1-one Sitagliptin-D4 HCL Hsdb 7516 C53323300 Metformin / sitagliptin Metformin hydrochloride mixture with sitagliptin phosphate Metformin mixture with sitagliptin
- CAS:486460-32-6
- MF:C16H15F6N5O
- MW:407.31
- EINECS:690-730-1
- Mol File:486460-32-6.mol
-
USE
Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral
drug launched for the treatment of type 2 diabetes. It acts by slowing the
inactivation of incretins, which are endogenous peptides involved in the physiologic
regulation of glucose homeostasis. Incretin hormones, including glucagonlike
peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP),
are released by the intestine throughout the day, and levels are increased in
response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b
cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers
glucagon secretion from pancreatic αcells, which leads to reduced hepatic
glucose production.
Lastest Price from Sitagliptin manufacturers
- Sitagliptin
-
- US $100.00 /kg
- CAS:486460-32-6
- Min. Order: 1kg
- Purity: 99
- Supply Ability: 5000
- 2024-12-26
- Sitagliptin
-
- US $0.00-0.00/Kg/Bag
- CAS:486460-32-6
- Min. Order: 1Kg/Bag
- Purity: 98.5% up
- Supply Ability: 20tons
- 2024-12-26
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- Company Name:AnHui HaiKang Pharmaceutical Co., Ltd.
- Tel:0556-5800026 17709662922
- Products Intro:Product Name:Sitagliptin
CAS:486460-32-6
Purity:99 Package:25kg/tub Remarks:KG More... - CB Index:55
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- Company Name:Ningbo Zhenlei Chemical Co.,ltd.
- Tel:0576-88808091 13958565781
- Products Intro:Product Name:Sitagliptin free base
CAS:486460-32-6
Purity:99% HPLC Package:25KG; - CB Index:58
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- Company Name:Anhui Cheer-Our Medical technology Co.,Ltd
- Tel:0551-63535381 13485700777
- Products Intro:Product Name:Sitagliptin
CAS:486460-32-6
Purity:99% Package:25kg - CB Index:58
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- Company Name:ChemFuture PharmaTech (Jiangsu) Ltd
- Tel:5108538618
- Products Intro:Product Name:Sitagliptin
CAS:486460-32-6
More... - CB Index:65
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Sitagliptin
CAS:486460-32-6
Remarks:C14173 More... - CB Index:61
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- Company Name:Beijing HwrkChemical Technology Co., Ltd
- Tel:010-89508211 18501085097
- Products Intro:Product Name:(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
CAS:486460-32-6
Purity:97.00% Package:10g Remarks:HWG49425 - CB Index:55
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- Company Name:Shanghai Scientia Pharmaceutical Technology Co., Ltd.
- Tel:21-21-54301573 13917723525
- Products Intro:Product Name:Sitagliptin
CAS:486460-32-6
Purity:99%min Package:50g;100g;250g;500g;1kg;5kg;10kg;25kg;50kg More... - CB Index:62
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