Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解性
DMSO: 38 mg/mL, soluble
外見
solid
酸解離定数(Pka)
11.32±0.46(Predicted)
色
Pale yellow
安定性：
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey
INVTYAOGFAGBOE-UHFFFAOYSA-N
安全情報
絵表示(GHS)
注意喚起語
Danger
危険有害性情報
H301：飲み込むと有毒
H360：生殖能または胎児への悪影響のおそれ
注意書き
P201：使用前に取扱説明書を入手すること。
説明
MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM). However, it does not inhibit HDAC8 (IC50 > 100 μM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo. Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin, inhibitors of poly (ADP-ribose) polymerase (PARP), or inhibitors of heat shock protein 90 (Hsp90).
