≤1mg/ml in ethanol;10mg/ml in DMSO;15mg/ml in dimethyl formamide
外見
crystalline solid
色
Off-white to light yellow
SMILES
C1=CC=C(C=C1)CC2=CC=C(C=C2)C3=CSC(=N3)N
説明
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 μM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 μM). ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.
