トリシアロガングリオシド-GT1b ウシ脳由来 Trisialoganglioside-GT1b from bovine brain
Sigma-Aldrich Japan
860059P
1mg
￥61300
ガングリオシドGT1b Ganglioside GT1b
Sigma-Aldrich Japan
860059P
5mg
￥198000
ガングリオシドGT1b Ganglioside GT1b
Sigma-Aldrich Japan
G3767
5mg
￥199000
トリシアロガングリオシド-GT1b ウシ脳由来 Trisialoganglioside-GT1b from bovine brain
プロパティ
貯蔵温度
−20°C
溶解性
DMSO: soluble
外見
lyophilized powder
色
Off-White
InChIKey
NVNPEYQWKCQBBU-ADMXJUBYSA-N
説明
Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cellular signaling events. Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. Ganglioside GT1b has inhibitory effects towards human humoral immune responses. At 0.1-10 μM, it can inhibit spontaneous IgG, IgM, and IgA production by human peripheral blood mononuclear cells. It has also been proposed as a host cell receptor for the Merkel cell polyomavirus and as a means to enable the initiation of an infection leading to Merkel cell carcinoma.
