C75 is stable fatty acid synthase (FASN) inhibitor that when administered in racemic form leads to profound weight loss and feeding inhibition in both high-
fat diet wild type obese and leptin-
deficient
ob/ob mice.
1 C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-
coenzyme A in cells with an upregulated FASN pathway.
2 (?)-
trans-
C75 is an enantiomer of C75.
3 Its biologicial activity has not been reported.
