Buserelin acetate is a potent analog of the hypothalamic hormone, luteinizing
hormone-releasing hormone (LH-RH). Chronic administration of higher doses of
buserelin desensitizes the pituitary, resulting in a decreased production of
luteinizing hormone (LH), follicle stimulating hormone (FSH), and eventually
sex steroids (testosterone in males and estradiol in females). Initial approval is
for use in achieving medical castration in the treatment of advanced prostate
cancer. It has also been investigated for the treatment of endometriosis,
leiomyoma, precocious puberty, advanced breast cancer and infertility.
