Treprostinil

$13 - $34072.5

Product nameTreprostinil
Cas No81846-19-7
MFC23H34O5
MW390.51
EINECS808-233-7
MDL NumberMFCD00888847

Synonyms

2-[[[(1R,2R,3aS,9aS)-2α-Hydroxy-1β-[(S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-benzo[f]indene]-5-yl]oxy]acetic acid;UT-15;[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid;Treprostinil Sodium intermediate;[1R-[1α(S*),2β,3aα,9aα]]-;2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic Acid;Acetic acid, 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-;U 62840

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Price

71 prices

Brand less more

aablocks ChemScene Biorbyt Ltd Matrix Scientific Cayman Chemical TRC AvaChem ACHEMBLOCK American Custom Chemicals Corporation DC Chemicals CSNpharm Tocris Biosynth AK Scientific AHH Crysdot
Package less more

2mg 10 10mm*1mlindmso 1mg 5mg 10.00mg 10mg 25mg 0.025g 25.00mg 50.00mg 50mg 100mg 200mg 1mlx10mm(indmso) 250mg 1g

Clear All Done

Brand	Packaging	Price	Product name
aablocks AA005HQU	1mg	$13	Rumodolin
aablocks AA005HQU	5mg	$31	Rumodolin
aablocks AA005HQU	10mg	$47	Rumodolin
aablocks AA005HQU	25mg	$83	Rumodolin
aablocks AA005HQU	50mg	$144	Rumodolin
aablocks AA005HQU	100mg	$214	Rumodolin
ACHEMBLOCK Y228467	100MG	$195	Treprostinil
ACHEMBLOCK Y228467	250MG	$350	Treprostinil
ACHEMBLOCK Y228467	1G	$1050	Treprostinil
AHH MT-58412	0.025g	$790	Remodulin

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Properties

Melting point	121-123°
Boiling point	587.1±50.0 °C(Predicted)
Density	1.158±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form	Solid
pka	3.19±0.10(Predicted)
color	Off-White to Beige
optical activity	[α]/D 40 to 50°, c =0.5 in methanol
InChIKey	PAJMKGZZBBTTOY-ZFORQUDYSA-N
SMILES	C(O)(=O)COC1=C2C(=CC=C1)C[C@@]1([H])[C@@]([H])(C2)C[C@@H](O)[C@@H]1CC[C@@H](O)CCCCC

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H301：Toxic if swalloed

H311：Toxic in contact with skin

H331：Toxic if inhaled

H361：Suspected of damaging fertility or the unborn child

Precautionary statements

P201：Obtain special instructions before use.

P202：Do not handle until all safety precautions have been read and understood.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313：IF exposed or concerned: Get medical advice/attention.

P405：Store locked up.

P501：Dispose of contents/container to..…

Description

Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by increasing pulmonary arterial and vascular resistance. Treprostinil is a stable analog of prostacyclin that is used clinically for the treatment of PPH under the trade name Remodulin?. The structural modifications in treprostinil compared to prostacyclin increase the plasma half-life from 2 minutes to 34 and 85 minutes for intravenous and subcutaneous infusion of the drug, respectively. In addition to treprostinil’s direct vasodilatory effects, it also inhibits inflammatory cytokine (TNFα, IL-1β, IL-6, GM-CF) production by human alveolar macrophages in the sub-micromolar range by preventing NF-κB translocation to the nucleus.

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Suppliers and manufacturers

career henan chemical co

$7.00

REMODULIN

CAS: 81846-19-7
Protheragen-ING
Suzhou ARTK Medchem Co., Ltd.
Shanghai finete Pharmaceutical Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Lianyungang happen teng technology co., LTD
Biochempartner
HubeiwidelychemicaltechnologyCo.,Ltd
BOC Sciences
Chengdu Aslee Biopharmaceuticals, Inc.

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2-[[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid,2-(2-hydroxyethylamino)ethanol
Phenoxyacetic acid sodium salt

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