Torin 1

$28 - $4500

Product nameTorin 1
Cas No1222998-36-8
MFC35H28F3N5O2
MW607.62
MDL NumberMFCD18782653

Synonyms

1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one;1-[4-(4-PROPANOYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL]-9-QUINOLIN-3-YLBENZO[H][1,6]NAPHTHYRIDIN-2-ONE;Torin 1;Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-;1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one Torin 1;Torin 1 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one;1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one;Torin 1, >=98%

show less show more

Price

56 prices

Brand less more

Sigma-Aldrich Cayman Chemical Arctom Crysdot ACHEMBLOCK Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology Matrix Scientific AK Scientific Axon Medchem Medical Isotopes, Inc. ChemScene Biosynth DC Chemicals
Package less more

1unit 10.00mg 25.00mg 50.00mg 10mm*1mlindmso 200mg 250mg 500mg 5mg 10mg 25mg 50mg 1g 100mg 10 50

Clear All Done

Brand	Packaging	Price	Product name
ACHEMBLOCK 10730	5MG	$75	Torin 1
ACHEMBLOCK 10730	25MG	$215	Torin 1
ACHEMBLOCK 10730	100MG	$650	Torin 1
ACHEMBLOCK 10730	1G	$2150	Torin 1
AK Scientific Y0294	50mg	$640	Torin1
AK Scientific Y0294	10mg	$218	Torin1
ApexBio Technology A8312	1unit	$28	Torin1
ApexBio Technology A8312	5mg	$70	Torin1
ApexBio Technology A8312	25mg	$270	Torin1
Arctom HY-13003	50mg	$380	Torin1

1of6

Properties

Melting point	>223°C (dec.)
Boiling point	817.2±65.0 °C(Predicted)
Density	1.362
storage temp.	+2C to +8C
solubility	Soluble in DMSO (up to 8 mg/ml).
form	Yellowish-white powder
pka	4.19±0.20(Predicted)
color	White or off-white
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey	AKCRNFFTGXBONI-UHFFFAOYSA-N
SMILES	N1(C2=CC=C(N3CCN(C(=O)CC)CC3)C(C(F)(F)F)=C2)C2=C(C=NC3=CC=C(C4=CC5C(N=C4)=CC=CC=5)C=C32)C=CC1=O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H320：Causes eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.

Related product price

Rapamycin $9-6160 Pictilisib (GDC-0941) $30-3563.2 KU-0063794 $50-2839

Suppliers and manufacturers

career henan chemical co

$2.00/1kg

1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one

CAS:1222998-36-8
ATK CHEMICAL COMPANY LIMITED
Biochempartner
CONIER CHEM AND PHARMA LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
HANGZHOU LEAP CHEM CO., LTD.
TargetMol Chemicals Inc.

More related product prices

Rapamycin
Pictilisib (GDC-0941)
KU-0063794
1223001-51-1
PP242

Everolimus
AC480 (BMS-599626)
Unii-U2Y5ofn795
CUDC-101
RO4929097

Avagacestat (BMS-708163)
402957-28-2
958852-01-2
1072833-77-2
CCT 137690

ACP196
Tariquidar

1of4

Send Inquriy