TQS;3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide;4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide;Inhibitor,modulator,acetylcholine,Nicotinic acetylcholine receptors,nAChR,allosteric,neuroinflammatory,positive,pain,inhibit,TQS,nicotinic;3H-Cyclopenta[c]quinoline-8-sulfonamide, 3a,4,5,9b-tetrahydro-4-(1-naphthalenyl)-;TQS, 10 mM in DMSO
TQS is a positive allosteric modulator (Type II) of alpha7 nACh receptors, functional human α7 nicotinic acetylcholine receptor (nAChR) generated from Escherichia coli that opens a new avenue for producing mammalian Cys-loop receptors to facilitate structure-based rational drug design.
