Curcuminoids are natural and synthetic analogs of curcumin , a natural polyphenol with modulating effects in inflammation, cancer, and immunity. Salicylcurcumin is a synthetic curcuminoid which, like bisdemethoxycurcumin , lacks methoxy groups on both phenols. Furthermore, the hydroxyl groups on each phenol are positioned ortho, as in salicylates, rather than in the para position typical of curcuminoids. Salicylcurcumin has antioxidant and anticarcinogenic properties. Also, it increases the activity of quinone reductase in mouse hepatoma cells in a dose-dependent fashion, doubling activity at 0.3 μM salicylcurcumin.
