Description
Curcuminoids are natural and synthetic analogs of curcumin , a natural polyphenol with modulating effects in inflammation, cancer, and immunity.
1 Salicylcurcumin is a synthetic curcuminoid which, like bisdemethoxycurcumin , lacks methoxy groups on both phenols. Furthermore, the hydroxyl groups on each phenol are positioned
ortho, as in salicylates, rather than in the
para position typical of curcuminoids. Salicylcurcumin has antioxidant and anticarcinogenic properties.
2,3 Also, it increases the activity of quinone reductase in mouse hepatoma cells in a dose-dependent fashion, doubling activity at 0.3 μM salicylcurcumin.
4,5
References
1. Grynkiewicz, G., and Slifirski, P. Curcumin and curcuminoids in quest for medicinal status Acta Biochim. Pol. 59(2),201-212(2012).
2. Manju, M., Sherin, T.G., Rajasekharan, K.N., et al. Curcumin analogue inhibits lipid peroxidation in a freshwater teleost, Anabas testudineus (Bloch)--an in vitro and in vivo study Fish Physiol. Biochem. 35(3),413-420(2009).
3. Anto, R.J., George, J., Babu, K.V., et al. Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids Mutat. Res. 370(2),127-131(1996).
4. Dinkova-Kostova, A.T., and Talalay, P. Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes Carcinogenesis 20(5),911-914(1999).
5. Magesh, S., Chen, Y., and Hu, L. Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Med. Res. Rev. 32(4),687-726(2012).
