The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group.1,2,3 There are seven human sirtuins, which have been designated SIRT1-7.4 SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-κB signaling.5,6 Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature ageing disorder, and have a shortened life span.5,6 Since SIRT6 binds and attenuates NF-κB signaling, it is proposed that activators of SIRT6 may be effective anti-cancer and anti-inflammatory drugs and may increase longevity.5WARNING This product is not for human or veterinary use.
