Histone deacetylase 4 (HDAC4) is a zinc-dependent metalloenzyme and class IIa HDAC.1 It is composed of an N-terminal regulatory domain, which contains a myocyte-specific enhancer factor 2 (MEF2) binding site, three 14-3-3 binding sites, a nuclear localization signal, and a caspase-3 cleavage site, a catalytic domain, and a C-terminal domain that contains a nuclear export signal. HDAC4 shuttles between the cytoplasm and nucleus and is mainly expressed in skeletal muscle, brain, ovaries, and colon but is also found in the small intestine, heart, kidney, testis, thymus, and leukocytes.2,3 It acts as a transcriptional corepressor and has many binding partners, including the transcription factors MEF2 and RUNX family transcription factor 2 (RUNX2).1,4 Knockout of Hdac4 induces premature ossification and chondrocyte hypertrophy in mice.4 Mutations in HDAC4 are associated with brachydactyly-mental retardation syndrome, a disorder characterized by brachydactyly type E, intellectual disability, and facial dysmorphisms.5 Cayman’s HDAC4 (human, recombinant) protein can be used for enzyme activity assays.WARNING This product is not for human or veterinary use.
