SB216763

$25 - $1802

Product nameSB216763
Cas No280744-09-4
MFC19H12Cl2N2O2
MW371.22
MDL NumberMFCD09753369

Synonyms

SB 216763;3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE;3-(2,4-Dichlorophenyl)-4-...;3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione;SB-216763(SB 216763);GSK-3 Inhibitor IV, SB-216763 ;CS-332;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem

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TCI Chemical Sigma-Aldrich Cayman Chemical CSNpharm Arctom Chemenu Crysdot AvaChem Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology Matrix Scientific Adipogen Life Sciences Axon Medchem ChemScene SynQuest Laboratories Biosynth Ambeed Labseeker DC Chemicals
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5.00mg 10.00mg 1 50 50.00mg 10mm*1mlindmso 2x10mg 2x50mg 100.00mg 500mg 10g 10mm*1mlindmso(solid+solvent) 1mg 5mg 10mg 25mg 50mg 100mg 250mg 1g 5g 10mm*1mlindmso(solution)

Clear All Done

Brand	Packaging	Price	Product name
Adipogen Life Sciences AG-CR1-3659-M001	1mg	$30	SB 216763
Adipogen Life Sciences AG-CR1-3659-M001	1mg	$30	SB216763
Adipogen Life Sciences AG-CR1-3659-M005	5mg	$60	SB216763
Adipogen Life Sciences AG-CR1-3659-M025	25mg	$280	SB216763
Ambeed A100785	1g	$368	SB 216763
Ambeed A100785	250mg	$153	SB 216763
Ambeed A100785	5mg	$42	SB 216763
Ambeed A100785	1mg	$25	SB 216763
Ambeed A100785	10mg	$54	SB 216763
Ambeed A100785	50mg	$82	SB 216763

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Properties

Melting point	287-288.6 °C(lit.)
Boiling point	598.1±50.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: 20 mg/mL, soluble
form	Orange solid
pka	7.27±0.60(Predicted)
color	orange
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI	InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
InChIKey	JCSGFHVFHSKIJH-UHFFFAOYSA-N
SMILES	N1C(=O)C(C2C3=C(N(C)C=2)C=CC=C3)=C(C2=CC=C(Cl)C=C2Cl)C1=O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

SB 216763 is a cell-permeable, potent, selective and ATP-competitive inhibitor of GSK-3 (Glycogen Synthase Kinase) with an IC₅₀ value of 34 nM for GSK-3α and with similar potency for GSK-3β. In PC-12 cells, SB-216763 exhibits neuroprotective properties and protects cultured central and peripheral nervous system neurones from cell death. Furthermore, SB-216763 increases the concentration of cytoplasmic β-catenin through a GSK-3 dependent manner. These inhibitory effects are similar to those of Wnt.

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Suppliers and manufacturers

career henan chemical co

$2.00/1kg

SB216763

CAS:280744-09-4
TargetMol Chemicals Inc.

$33.00/2mg

SB 216763

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Hong Kong Tiansheng New Material Trading Co., Ltd

$19.00/1KG

SB216763

CAS:280744-09-4
ATK CHEMICAL COMPANY LIMITED
Biochempartner
CONIER CHEM AND PHARMA LIMITED
Dideu Industries Group Limited
Finetech Industry Limited
Dayang Chem (Hangzhou) Co.,Ltd.
Zhejiang J&C Biological Technology Co.,Limited

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