insoluble in H2O; ≥10.9 mg/mL in DMSO; ≥69.1 mg/mL in EtOH
form
A crystalline solid
pka
4.14±0.10(Predicted)
color
White to off-white
Safety Information
Symbol(GHS)
Signal word
Danger
Hazard statements
H301：Toxic if swalloed
Precautionary statements
P264：Wash hands thoroughly after handling.
P264：Wash skin thouroughly after handling.
P270：Do not eat, drink or smoke when using this product.
P405：Store locked up.
P501：Dispose of contents/container to..…
Description
(S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor. In the 2-aryl propionic acid NSAID family, Cox inhibition resides primarily in the (S)-enantiomer. In guinea pig whole blood, the IC50 value of (S)-flurbiprofen is about 0.5 μM for both Cox-1 and Cox-2. Only a small amount (<5%) of the (S)-enantiomer is converted to the (R)-enantiomer in rats and humans. Therefore, the biological effects are specific to each enantiomer of (S)-(+)-Flurbiprofen.
