Treprostinil

$97 - $34072.5

Product nameTreprostinil
Cas No81846-19-7
MFC23H34O5
MW390.51
EINECS808-233-7
MDL NumberMFCD00888847

Synonyms

2-[[[(1R,2R,3aS,9aS)-2α-Hydroxy-1β-[(S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-benzo[f]indene]-5-yl]oxy]acetic acid;UT-15;[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid;Treprostinil Sodium intermediate;[1R-[1α(S*),2β,3aα,9aα]]-;2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic Acid;Acetic acid, 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-;REMODULIN

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Price

20 prices

Brand less more

Cayman Chemical AHH CSNpharm Crysdot Tocris TRC Biorbyt Ltd AK Scientific ChemScene American Custom Chemicals Corporation DC Chemicals
Package less more

2mg 10 1mg 5mg 10mg 25mg 0.025g 100mg 250mg 1g

Clear All Done

Brand	Packaging	Price	Product name
AHH MT-58412	0.025g	$790	Remodulin
AK Scientific 2025AH	10mg	$523	Remodulin
American Custom Chemicals Corporation API0004481	1MG	$202.65	TREPROSTINIL
American Custom Chemicals Corporation API0004481	1G	$34072.5	TREPROSTINIL
Biorbyt Ltd orb573008	250mg	$1949.9	Treprostinil free acid
Biorbyt Ltd orb573008	1g	$3876	Treprostinil free acid
Biorbyt Ltd orb573008	100mg	$1133.9	Treprostinil free acid
Cayman Chemical 10162	5mg	$433	Treprostinil
Cayman Chemical 10162	10mg	$768	Treprostinil
Cayman Chemical 10162	1mg	$97	Treprostinil

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Properties

Melting point	121-123°
Boiling point	587.1±50.0 °C(Predicted)
Density	1.158±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form	Solid
pka	3.19±0.10(Predicted)
color	Off-White to Beige
InChIKey	PAJMKGZZBBTTOY-ZFORQUDYSA-N
SMILES	C(O)(=O)COC1=C2C(=CC=C1)C[C@@]1([H])[C@@]([H])(C2)C[C@@H](O)[C@@H]1CC[C@@H](O)CCCCC

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H301：Toxic if swalloed

H311：Toxic in contact with skin

H331：Toxic if inhaled

H361：Suspected of damaging fertility or the unborn child

Precautionary statements

P201：Obtain special instructions before use.

P202：Do not handle until all safety precautions have been read and understood.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313：IF exposed or concerned: Get medical advice/attention.

P405：Store locked up.

P501：Dispose of contents/container to..…

Description

Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by increasing pulmonary arterial and vascular resistance. Treprostinil is a stable analog of prostacyclin that is used clinically for the treatment of PPH under the trade name Remodulin?. The structural modifications in treprostinil compared to prostacyclin increase the plasma half-life from 2 minutes to 34 and 85 minutes for intravenous and subcutaneous infusion of the drug, respectively. In addition to treprostinil’s direct vasodilatory effects, it also inhibits inflammatory cytokine (TNFα, IL-1β, IL-6, GM-CF) production by human alveolar macrophages in the sub-micromolar range by preventing NF-κB translocation to the nucleus.

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Suppliers and manufacturers

Protheragen-ING
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Biochempartner
Hubei Jusheng Technology Co.,Ltd.
HubeiwidelychemicaltechnologyCo.,Ltd
Hubei xin bonus chemical co. LTD
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2-[[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid,2-(2-hydroxyethylamino)ethanol
Phenoxyacetic acid sodium salt

REMODULIN

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