RADICICOL

$32 - $835

Product nameRADICICOL
Cas No12772-57-5
MFC18H17ClO6
MW364.78
MDL NumberMFCD06795865

Synonyms

(1AR,2Z,4E,14R,15AR)-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE;[1AS-(1AR*,2Z,4E,14*,15AR*)]-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE;5-CHLORO-6-(7,8-EPOXY-10-HYDROXY-2-OXO-3,5-UNDECADIENYL)-BETA-RESORCYLIC ACID MU-LACTONE;FO-4910;KF58332;KF9-A;MONORDEN;MONORODENE

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Price

26 prices

Brand less more

Sigma-Aldrich Cayman Chemical Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology AK Scientific Adipogen Life Sciences ChemScene Biosynth Carbosynth
Package less more

1 500μg 1mg 5mg

Clear All Done

Brand	Packaging	Price	Product name
Adipogen Life Sciences AG-CN2-0021-M001	1mg	$40	Radicicol
Adipogen Life Sciences AG-CN2-0021-M001	1mg	$45	Radicicol
Adipogen Life Sciences AG-CN2-0021-M005	5mg	$160	Radicicol
Adipogen Life Sciences AG-CN2-0021-M005	5mg	$180	Radicicol
AK Scientific 2024AH	5mg	$302	Radicicol
ApexBio Technology A4067	5mg	$359	Radicicol
ApexBio Technology A4067	1mg	$74	Radicicol
ApexBio Technology A4067	1mg	$98	Radicicol
Biorbyt Ltd orb1706736	1mg	$180	Radicicol
Biosynth Carbosynth BR162744	5mg	$300	Radicicol

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Properties

Melting point	193.5°
alpha	D20 +203° (chloroform)
Boiling point	656.2±55.0 °C(Predicted)
Density	1.364±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	ethanol: 10 mg/mL
form	solid
pka	6.29±0.40(Predicted)
color	yellow
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI	1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3+
InChIKey	WYZWZEOGROVVHK-ZUVMSYQZSA-N
SMILES	Clc1c2c(c(cc1O)O)C(=O)OC(CC3OC3\C=C\C=C\C(=O)C2)C

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H301：Toxic if swalloed

H340：May cause genetic defects

H350：May cause cancer

Precautionary statements

P202：Do not handle until all safety precautions have been read and understood.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310：IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405：Store locked up.

Description

Radicicol is a natural product derived from D. chlamydosporia with antibiotic, antifungal, and antimalarial properties. It binds and inhibits heat shock protein 90 (Hsp90) with nanomolar affinity. This interaction inhibits p23 from associating with Hsp90, suppresses signaling through HIF-1α, and produces decreased levels of progesterone receptor, Raf-1, p185erb82, and mutant p53. Radicicol also binds to and inhibits DNA topoisomerase type II proteins and GRP94 through an ATPase domain common to Hsp90.

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Suppliers and manufacturers

career henan chemical co

$1.00/1KG

RADICICOL

CAS:12772-57-5
TargetMol Chemicals Inc.

$139.00/1mg

Radicicol

CAS:12772-57-5
BOC Sciences
Shaanxi Dideu Medichem Co. Ltd
Aladdin Scientific
NANJING YINGWEN BIOTECHNOLOGY CO LTD
J & K SCIENTIFIC LTD.
3B Pharmachem (Wuhan) International Co.,Ltd.
Beijing Ouhe Technology Co., Ltd
9ding chemical ( Shanghai) Limited

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