Pevonedistat

$49 - $4735.5

Product namePevonedistat
Cas No905579-51-3
MFC21H25N5O4S
MW443.52
MDL NumberMFCD17215201

Synonyms

((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)aMino)-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-2-hydroxycyclopentyl)Methyl sulfaMate;[(1S,2S,4R)-4-(4-{[(1S)-2,3-dihydro-1H-inden-1-yl]aMino}-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-2-hydroxycyclopentyl]Methyl sulfaMate;Pevonedistat;MLN4924 (Pevonedistat);Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimi;Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester;CS-821;TAK-924

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Price

33 prices

Brand less more

Cayman Chemical Chemenu Crysdot Tocris TRC ApexBio Technology Matrix Scientific AK Scientific Adipogen Life Sciences Axon Medchem ChemScene American Custom Chemicals Corporation Biosynth Carbosynth DC Chemicals
Package less more

2mg 2x5mg 50mg 200mg 250mg 1g 10mm(in1mldmso) 1mg 5mg 10mg 25mg 100mg 10

Clear All Done

Brand	Packaging	Price	Product name
Adipogen Life Sciences AG-CS1-0103-M001	1mg	$210	MLN4924[NAEInhibitor]Solution
AK Scientific SYN5699	100mg	$1660	MLN4924
American Custom Chemicals Corporation INB0000406	1MG	$1097.25	MLN-4924
American Custom Chemicals Corporation INB0000406	10MG	$4735.5	MLN-4924
ApexBio Technology B1036	100mg	$950	MLN4924
ApexBio Technology B1036	50mg	$580	MLN4924
ApexBio Technology B1036	10mg	$210	MLN4924
ApexBio Technology B1036	10mM(in 1mL DMSO)	$120	MLN4924
ApexBio Technology B1036	5mg	$130	MLN4924
Axon Medchem Axon2038	2x5mg	$220	MLN4924-Pevonedistat

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Properties

Melting point	161-163°C
Boiling point	721.0±70.0 °C(Predicted)
Density	1.62
storage temp.	-20°C Freezer
solubility	Soluble in DMSO (up to 10 mg/ml).
form	solid
pka	9.35±0.70(Predicted)
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey	MPUQHZXIXSTTDU-QXGSTGNESA-N
SMILES	S(N)(OC[C@@H]1C[C@@H](N2C3C(C=C2)=C(N[C@@H]2C4=C(C=CC=C4)CC2)N=CN=3)C[C@@H]1O)(=O)=O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates with roles relevant to cellular processes important for cancer cell survival. Neddylation of CRLs is initiated by NEDD8-activating enzyme (NAE), which has become a novel target in cancer therapeutic research. MLN4924 is an analog of adenosine 5’-monophosphate that selectively inhibits NAE (IC50 = 4.7 nM). At much higher concentrations, MLN4924 inhibits the related enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE) with IC50 values of 1.5 and 8.2 μM, respectively. At 0.3 μM, MLN4924 has been shown to disrupt CRL-mediated protein turnover leading to apoptosis in HCT-116 cells by deregulating S-phase DNA synthesis. In vivo, 30-60 mg/kg MLN4924 dose-dependently suppresses the growth of human tumor xenografts in mice.

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Suppliers and manufacturers

Hebei Mojin Biotechnology Co., Ltd

$0.00/25KG

Pevonedistat

CAS:905579-51-3
Wuhan Haorong Biotechnology Co.,ltd

$0.00/1KG

Pevonedistat

CAS:905579-51-3
TargetMol Chemicals Inc.

$48.00/1mg

Pevonedistat

CAS:905579-51-3
Career Henan Chemica Co

$1.00/1g

Pevonedistat

CAS:905579-51-3
ATK CHEMICAL COMPANY LIMITED
Nanjing ChemLin Chemical Industry Co., Ltd.
Hubei xin bonus chemical co. LTD
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED

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