PPAHV is a non-pungent resiniferatoxin-type phorboid vanilloid. Agonist at rat VR1(TRPV1) (EC50 between 3 and 10 μM) but virtually inactive at human VR1(TRPV1) (EC50>10 μM). PPAHV additionally induces apoptosis through a TRPV-independent mechanism and is a tumor promotor.