OLIGOMYCIN B;OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES;Oligomycin A, 28-oxo- ;Oligomycin B fromStreptomyces diastatochromogenes;28-Oxooligomycin A;OligoMycin B froM StreptoMyces;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,3',9,13(4'H)-tetrone, 22-ethyl-5',6'-dihydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-;OLIGOMYCIN B USP/EP/BP
≤30mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
pka
12.52±0.70(Predicted)
form
White to off-white powder.
color
White to off-white
Merck
13,6902
Safety Information
Symbol(GHS)
Signal word
Warning
Hazard statements
H302：Harmful if swallowed
Precautionary statements
P264：Wash hands thoroughly after handling.
P264：Wash skin thouroughly after handling.
P270：Do not eat, drink or smoke when using this product.
P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
Description
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin B is a nonselective inhibitor of the mitochondrial F1FO ATP synthase. Oligomycin B (1-10 μM) can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.
