O-1918 is an analog of cannabidiol acting as a selective antagonist at the endothelial non-CB1/CB2 cannabinoid receptor. O-1918 induces endothelium-dependent vasodilation via a CB1/CB2/nitric oxide-independent mechanism. O-1918 blocks the abnormal cannabidiol-induced activation of the PI3-kinase/Akt pathway in vein endothelial cells. O-1918 is an inhibitor of GPR18.
